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Hyaluronan synthase (PmHAS)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (10) ATP Synthase (14) Cyclic GMP-AMP Synthase (7) Fatty Acid Synthase (FASN) (23) Glucosylceramide Synthase (GCS) (19) GSK-3 (25) NO Synthase (84) PGE synthase (22) Thymidylate Synthase (17) Acyltransferase (3) Adenosine Kinase (1) Adenosine Receptor (1) Akt (1) Aminoacyl-tRNA Synthetase (1) AMPK (1) Antibiotic (19) Antifolate (6) Apoptosis (34) Autophagy (11) Bacterial (34) Biochemical Assay Reagents (6) c-Kit (1) Calcium Channel (3) Caspase (1) CDK (3) Cholinesterase (ChE) (1) COX (11) Cuproptosis (1) Cytochrome P450 (7) Dengue virus (1) Dihydroorotate Dehydrogenase (1) DNA Methyltransferase (1) DNA/RNA Synthesis (13) Drug Metabolite (2) EGFR (2) Endogenous Metabolite (59) ERK (1) Farnesyl Transferase (3) Ferroptosis (1) Flavivirus (1) Fluorescent Dye (3) Fungal (29) Glutathione S-transferase (1) Guanylate Cyclase (3) HCV (2) HIF/HIF Prolyl-Hydroxylase (1) Histamine Receptor (1) HMG-CoA Reductase (HMGCR) (2) HSV (3) iGluR (2) IKK (1) Imidazoline Receptor (1) Interleukin Related (4) IRAK (1) Isotope-Labeled Compounds (30) JNK (1) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (1) Lipoxygenase (2) Microtubule/Tubulin (3) Mineralocorticoid Receptor (6) Mitochondrial Metabolism (1) Monoamine Oxidase (2) mTOR (3) NF-κB (5) NOD-like Receptor (NLR) (1) Nucleoside Antimetabolite/Analog (16) Orthopoxvirus (2) Oxidative Phosphorylation (2) Parasite (6) Phosphatase (1) Phosphodiesterase (PDE) (2) Phospholipase (1) PKC (2) Progesterone Receptor (1) Prostaglandin Receptor (15) PROTACs (1) Ras (1) Reactive Oxygen Species (4) ROS Kinase (1) RSV (1) SARS-CoV (2) Serotonin Transporter (1) Small Interfering RNA (siRNA) (1) STING (1) Thrombin (2) TNF Receptor (1) VEGFR (1)
By Research Areas:	Cancer (144) Cardiovascular Disease (47) Endocrinology (12) Infection (85) Inflammation/Immunology (106) Metabolic Disease (68) Neurological Disease (79)
Click Chemistry:	Azide (1) Alkynes (5)

494

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

*Polyketide synthase* 13-IN-1**	Others	Infection Inflammation/Immunology
Polyketide synthase 13-IN-1 (compound 32) is a *polyketide synthase* 13** inhibitor .

*Polyketide synthase* 13-IN-2**	Bacterial	Infection Inflammation/Immunology
Polyketide synthase 13-IN-2 (comp 42) is a *polyketide synthase* 13** inhibitor against Mycobacterium tuberculosis, with an MIC of 0.25 μg/mL .

*Chitin synthase* inhibitor 9**	Fungal	Infection
Chitin synthase inhibitor 9 is a *chitin synthase* (CHS)** inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 9 can be used in the research of fungi infection .

*Chitin synthase* inhibitor 8**	Fungal	Infection
Chitin synthase inhibitor 8 is a *chitin synthase* (CHS)** inhibitor with broad-spectrum antifungal activity. Chitin synthase inhibitor 8 can be used in the research of fungi infection .

*Chitin synthase* inhibitor 7**	Fungal	Infection
Chitin synthase inhibitor 7 (compound 9c) is a potent *chitin synthase* (CHS) inhibitor with an IC₅₀** value of 0.37 mM. Chitin synthase inhibitor 7 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 7 can be used in the research of fungi infection .

*Chitin synthase* inhibitor 6**	Fungal	Infection
Chitin synthase inhibitor 6 (compound 9b) is a potent *chitin synthase* (CHS) inhibitor with an IC₅₀** value of 0.21 mM. Chitin synthase inhibitor 6 has broad-spectrum antifungal activity against drug-resistant fungi. Chitin synthase inhibitor 6 can be used in the research of fungi infection .

*Polyketide synthase* 13-IN-3**	Others	Infection Inflammation/Immunology
Polyketide synthase 13-IN-3 (compound 41) is a *polyketide synthase* 13** inhibitor，with a MIC of 0.0625-0.125 μg/mL against the M. tuberculosis strain H37Rv .

*Chitin synthase* inhibitor 14**	Fungal	Infection
Chitin synthase inhibitor 14 (compound 4n) is chitin synthase (CHS) inhibitor. Chitin synthase inhibitor 14 has antifungal activity while possessed the potency against drug-resistant fungal variants .

*S.pombe lumazine synthase-IN-1*	Bacterial Fungal	Infection
S.pombe lumazine synthase-IN-1 is an inhibitor of lumazine synthases with K_i values of 243 μM and 9.6 μM for *Schizosaccharomyces pombe* and **Mycobacterium tuberculosis lumazine synthases**, respectively .

*Glucosylceramide synthase-IN-3*	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-3 (compound BZ1) is a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS) inhibitor with IC₅₀*s of 16 nM for human GCS.Glucosylceramide synthase*-IN-3 can be used for Gaucher's disease research .

*Chitin synthase* inhibitor 3**	Fungal	Infection
Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC₅₀ value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity .

*Mtb ATP synthase-IN-1*	Bacterial ATP Synthase	Infection
Mtb ATP synthase-IN-1 (compound 6ab) is a potent **Mycobacterium tuberculosis (Mtb) ATP synthase** inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC₅₀ > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .

*Glucosylceramide synthase-IN-2*	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS) inhibitor with IC₅₀*s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase*-IN-2 can be used for Gaucher's disease research .

TP-060 Glucosylceramide synthase-IN-1	Glucosylceramide Synthase (GCS)	Neurological Disease Metabolic Disease
Glucosylceramide synthase-IN-1 (T-036) a potent, brain-penetrant and orally active *glucosylceramide synthase* (GCS) inhibitor with IC₅₀*s of 31 nM and 51 nM for human GCS and mouse GCS, respectively. Glucosylceramide synthase*-IN-1 can be used for Gaucher's disease research .

*Chitin synthase* inhibitor 11**	Fungal	Infection Cancer
Chitin synthase inhibitor 11 is a chitin synthase inhibitor. Chitin synthase inhibitor 11 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.10 mM. Chitin synthase inhibitor 11 has broad-spectrum antifungal activity in vitro. Chitin synthase inhibitor 11 can be used for the research of invasive fungal infections (IFIs) .

*Chitin synthase* inhibitor 2**	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC₅₀ value of 0.09 mM and the K_i value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B .

*Chitin synthase* inhibitor 10**	Fungal	Infection Cancer
Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs) .

*Chitin synthase* inhibitor 12**	Fungal	Infection Cancer
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC₅₀ value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs) .

*Dihydropteroate synthase-IN-1*	Bacterial	Infection
Dihydropteroate synthase-IN-1 (compound 5g) is a potent *dihydropteroate synthase* (DHPS)** inhibitor. Dihydropteroate synthase-IN-1 shows antimicrobial activities and antifungal activity. Dihydropteroate synthase-IN-1 inhibits cytochromes P450. Dihydropteroate synthase-IN-1 can bu used as diagnostic radio imaging material .

*Glucosylceramide synthase-IN-4*	Glucosylceramide Synthase (GCS)	Neurological Disease
Glucosylceramide synthase-IN-4 (compound 12) is a potent *glucosylceramide synthase* (GCS) inhibitor, with an IC₅₀** of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity .

*Chitin synthase* inhibitor 4**	Fungal	Infection
Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture .

*Squalene synthase-IN-1*	Others	Metabolic Disease
Squalene synthase-IN-1 (compound 1) is a potent antihyperlipidemic agent acting through Squalene Synthase inhibition. Squalene synthase-IN-1 exhibits an outstanding antioxidant and anti-inflammatory activity. Squalene synthase-IN-1 displays a significant reduction not only of glucose but also of oxidative stress levels, while it did not cause any toxicity .

*Squalene synthase-IN-2*	Others	Metabolic Disease
Squalene synthase-IN-2 (comppund isomer A-(1S, 3R)-14i) is an orally active squalene synthase inhibitor with IC₅₀ values of 3.4, 99 nM for squalene synthase and cholesterol synthesis, respectively. Squalene synthase-IN-2 reduces plasma cholesterol and triglyceride .

*Chitin synthase* inhibitor 13**	Fungal	Infection
Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC₅₀ of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity .

Cystathionine β-synthase	Biochemical Assay Reagents	Others
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H₂S) .

*Chitin synthase* inhibitor 5**	Fungal	Infection
Chitin synthase inhibitor 5 (compound 9a) is an inhibitor of chitin synthase with an IC₅₀ value of 0.14 mM. Chitin synthase inhibitor 5 shows broad-spectrum antifungal activity in vitro and shows good inhibition to C. albicans, A. flavus, A. fumigatus and C. neoformans. Chitin synthase inhibitor 5 can be used for the research of fungal .

*Chitin synthase* inhibitor 1**	Fungal Antibiotic	Inflammation/Immunology
Chitin synthase inhibitor 1 is a potent and selective *chitin synthase* (CHS) inhibitor (IC₅₀*=0.12 mM). Chitin synthase* inhibitor 1 has potent antifungal activity against drug-resistant fungi variants .

*ATP synthase* inhibitor 2**	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

*GlcN-6-P Synthase-IN-1*	Bacterial Fungal Cytochrome P450	Infection
GlcN-6-P Synthase-IN-1 (Compound 4d) is a Glucosamine-6-phosphate (GlcN-6-P) synthase inhibitor with an IC₅₀ of 3.47 μM. GlcN-6-P Synthase-IN-1 exhibits significant antimicrobial activity. GlcN-6-P Synthase-IN-1 has good penetration in the CNS and is able to inhibit the cytochrome P450, CYP3A4 isoform .

*ATP synthase* inhibitor 2 TFA**	ATP Synthase Bacterial	Infection
ATP synthase inhibitor 2 (Compound 22) TFA is a Pseudomonas aeruginosa (PA) ATP synthase inhibitor (IC₅₀=10 μg/mL). ATP synthase inhibitor 2 TFA can inhibit Pseudomonas aeruginosa (PA) ATP synthesis activity completely at 128 μg/mL .

*Phospho-Glycogen Synthase* Peptide-2(substrate)**	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .

*Ac-CoA Synthase* Inhibitor1** 3 Publications Verification	RSV	Infection Metabolic Disease
Ac-CoA Synthase Inhibitor1 is a potent, reversible acetate-dependent acetyl-CoA synthetase 2 (ACSS2) inhibitor with an IC₅₀ of 0.6 µM . Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus (RSV) .

*ATP synthase* inhibitor 1**	ATP Synthase	Cardiovascular Disease
ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F₁/F_O-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels .

*Phospho-Glycogen Synthase* Peptide-2(substrate) TFA**	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .

*[Ala9,10, Lys11,12] Glycogen Synthase* (1-12)**	PKC	Neurological Disease
[Ala9,10, Lys11,12] Glycogen Synthase (1-12) is a selective substrate for phosphorylation by protein kinase C (PKC). [Ala9,10, Lys11,12] Glycogen Synthase (1-12) can be used to determine the activity of protein kinase C .

beta-1,3-Galactosyltransferase (CgtB) GM1-synthase	Endogenous Metabolite	Others
beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS ^SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS ^SIAL structure production .

5-trans U-44069	PGE synthase	Cardiovascular Disease
5-trans U-44069 is the trans isomer of the thromboxane receptor agonist U-44069 (HY-121825). 5-trans U-44069 inhibits prostaglandin E2 synthase activity .

L-NABE	NO Synthase	Cardiovascular Disease
L-NABE is a nitric oxide (NO) synthase inhibitor. L-NABE is also a potent endothelium dependent vasoconstrictor and inhibitor of relaxation .

Lucerastat NB-DGJ; N-(n-Butyl)deoxygalactonojirimycin	Glucosylceramide Synthase (GCS)	Metabolic Disease
Lucerastat, the galactose form of Miglustat, is an orally-available inhibitor of *glucosylceramide synthase* (GCS)**. Lucerastat has the potential for Fabry disease study .

MZ-101 GYS1-IN-2	Others	Metabolic Disease
MZ-101 is a *glycogen synthase* 1 (GYS1)** inhibitor. MZ-101 can used to study GYS1 -mediated disease .

Rustmicin Galbonolide A	Fungal	Infection
Rustmicin (Galbonolide A) is a potent antifungal agent. Rustmicin inhibits inositol phosphoceramide synthase. Rustmicin shows antifungal activity .

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Endogenous Metabolite Bacterial	Cancer
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

FIN56 5+ Cited Publications	Ferroptosis	Others
FIN56 is a specific inducer of ferroptosis. FIN56 induces ferroptosis by inducing degradation of GPX4. FIN56 also binds to and activates squalene synthase .

Rubranol	NO Synthase	Inflammation/Immunology
Rubranol is an inhibitor of NO Synthase. Rubranol inhibits LPS-induced NO production in activated macrophages with 74% inhibition .

C6 NBD Glucosylceramide	Fluorescent Dye	Others
C6 NBD Glucosylceramide is a glucosylceramide fluorescent derivative (Ex=466 nm, Em=535 nm). C6 NBD Glucosylceramide can be used to study the metabolism and internalization of glucosylceramide and also for the determination of glucosyl ceramide synthase activity .

D-threo-PPMP	Glucosylceramide Synthase (GCS)	Neurological Disease
D-threo-PPMP is a potent inhibitor of glucosylceramide (GlcCer) synthase. D-threo-PPMP can block karyokinesis and reduce cyst production .

Cat. No.	Product Name

HY-L089

Mitochondria-Targeted Compound Library

890 compounds

Mitochondria plays an important role in many vital processes in cells, including energy production, fatty-acid oxidation and the Tricarboxylic Acid (TCA) cycle, calcium signaling, permeability transition, apoptosis and heat production. At present, it is recognized that many diseases are associated with impaired mitochondrial function, such as increased accumulation of ROS and decreased OXPHOS and ATP production. Mitochondria are recognized as one of the most important targets for new drug design in cancer, cardiovascular, and neurological diseases, etc. Some small molecule drugs or biologics can act on mitochondria through various pathways, including ETC inhibition, OXPHOS uncoupling, mitochondrial Ca²⁺ modulation, and control of oxidative stress via decrease or increase of mitochondrial ROS accumulation.

MCE supplies a unique collection of 890 mitochondria-targeted compound that mainly targeting Mitochondrial Metabolism, ATP Synthase, Mitophagy, Reactive Oxygen Species, etc. MCE Mitochondria-Targeted Compound Library is a useful tool for mitochondria-targeted drug discovery and related research.

HY-L087

Anti-Obesity Compound Library

2338 compounds

Obesity is widely recognized as the largest and fastest growing public health problem and is associated with numerous chronic disorders including osteoarthritis, obstructive sleep apnea, gallstones, fatty liver disease, reproductive and gastrointestinal cancers, dyslipidemia, hypertension, type 2 diabetes, heart failure, coronary artery disease, stroke, etc. Although obesity has long been associated with serious health issues, it has only recently been regarded as a disease in the sense of being a specific target for medical therapy. Obesity may be viewed as the dysregulation of two physiological functions, appetite regulation and energy metabolism, which combine to create disordered energy balance. Consequently, developing obesity treatments that target novel pathways is a growing focus for both biopharmaceutical industries.

MCE Anti-Obesity Compound Library owns a unique collection of 2338 compounds, which mainly target signaling pathway of controlling appetite, fatty acid metabolism and energy expenditure, etc. This library is a useful tool for discovery anti-obesity drugs.

HY-L044

Nucleotide Compound Library

491 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 491 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-W356117

C6 NBD Glucosylceramide	Fluorescent Dyes/Probes
C6 NBD Glucosylceramide is a glucosylceramide fluorescent derivative (Ex=466 nm, Em=535 nm). C6 NBD Glucosylceramide can be used to study the metabolism and internalization of glucosylceramide and also for the determination of glucosyl ceramide synthase activity .

HY-D0145

7-Ethoxyresorufin 1 Publications Verification Resorufin ethyl ether	Chromogenic Substrates
7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase .

HY-14536

Methylene Blue

10+ Cited Publications

Basic Blue 9; CI-52015; Methylthioninium chloride

Chromogenic Assays

Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation .

HY-D1577

C6 NBD Lactosylceramide	Fluorescent Dyes/Probes
C6 NBD Lactosylceramide is a derivative of lactosylceramides, and can be used in lactosylceramide synthase assay as a fluorescent acceptor substrate. C6 NBD Lactosylceramide can also be used in cancer research .

HY-D1573

C6 NBD Phytoceramide

Fluorescent Dyes/Probes

C6 NBD Phytoceramide is a fluorescently labeled short-chain ceramide analog that can be recognized by mammalian GlcCer synthase (GCS) .

Cat. No.	Product Name	Type

HY-B0633A

Hyaluronic acid 10+ Cited Publications Hyaluronan; Hyaluronate	Drug Delivery
Hyaluronic acid (corn fermented) is a biopolymer composed of repeating units of disaccharides with various applications.

HY-P2739

Citrate synthase	Biochemical Assay Reagents
Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .

HY-E70078

Cystathionine β-synthase	Biochemical Assay Reagents
Cystathionine β-synthase is an enzyme that catalyzes the condensation of serine and homocysteine to water and cystathionine. Cystathionine β-synthase is a prominent enzyme for the production of hydrogen sulfide (H₂S) .

HY-E70050

beta-1,3-Galactosyltransferase (CgtB) GM1-synthase	Biochemical Assay Reagents
beta-1,3-Galactosyltransferase (CgtB) (GM1-synthase) is an enzyme that required for sialylated lipooligosaccharide (LOS ^SIAL) production, is often used in biochemical studies. beta-1,3-Galactosyltransferase (CgtB) catalyzes the addition of a galactose molecule, which is required for GM1-like LOS ^SIAL structure production .

HY-134136

Octanoyl Coenzyme A	Biochemical Assay Reagents
Octanoyl coenzyme A is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A can inhibit *citrate synthase* (CS) and glutamate dehydrogenase (GDH) with IC₅₀** values of 0.4-1.6 mM .

HY-E70049

beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) GM2/GD2 synthase	Biochemical Assay Reagents
beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) (GM2/GD2 synthase) is a key enzyme which catalyzes the conversion of GM3, GD3 and lactosylceramide (LacCer) to GM2, GD2 and asialo-GM2 (GA2), respectively. beta-1,4-N-Acetylgalactosaminyltransferase (CgtA) is a key enzyme to control the synthesis of brain-enriched complex gangliosides .

HY-134136A

Octanoyl coenzyme A lithium	Biochemical Assay Reagents
Octanoyl coenzyme A lithium is a fatty acyl coenzyme A derivative. Octanoyl coenzyme A lithium can inhibit citrate synthase (CS) and glutamate dehydrogenase (GDH) with IC₅₀ values of 0.4-1.6 mM .

HY-136830

ADP-Glucose disodium

Adenosine-5'-diphosphoglucose disodium

Biochemical Assay Reagents

ADP-Glucose disodiumIs an immediate precursor for the biosynthesis of storage polysaccharides in plants, green algae and cyanobacteria, and structural polysaccharides in some bacteria, by the addition of glucose. It is used to produce amylose, amylopectin, starch and other polysaccharides by amylose synthase or starch synthase in plastids. ADPGUsually produced in plastids, although it can be biosynthesized in the cytoplasm of some grasses and imported into plastids by membrane-bound transporters .

HY-134426

DL-β-Hydroxybutyryl coenzyme A lithium	Biochemical Assay Reagents
DL-β-Hydroxybutyryl coenzyme A lithium is an intermediate in the fermentation of butyric acid and the metabolism of lysine and tryptophan, and is produced from β-hydroxybutyric acid by short-chain-CoA synthase .

HY-E70057

alpha-2,8-Sialyltransferase (CstII) ST8Sia VI; GD3 synthase	Biochemical Assay Reagents
alpha-2,8-Sialyltransferase (CstII) (ST8Sia VI) is a member of alpha2,8-sialyltransferase (ST8Sia) family, is often used in biochemical studies. alpha-2,8-Sialyltransferase (CstII) catalyzes elongation of the α2,8-linked oligo/polysialic acid chain on the Sia residue transferred .

HY-W037200

2,3,5-Tri-O-benzyl-D-ribose 2,3,5-Tri-O-benzyl-D-ribofuranose	Cell Assay Reagents
2,3,5-Tri-O-benzyl-D-ribose (Compound 1) is an effective inhibitor of Botrytis cinerea chitin synthase (CHS) with an IC₅₀ value of 1.8 μM. 2,3,5-Tri-O-benzyl-D-ribose exhibits antifungal activity and is able to inhibit the B. cinerea BD90 strain, with a MIC value of 190 μM .

HY-N7833

(all-Z)-6,9,12,15,18-Heneicosapentaenoic Acid

Heneicosapentaenoic acid

Biochemical Assay Reagents

Heneicosapentaenoic Acid (HPA) is a 21:5 omega-3 fatty acid found in trace amounts in the green alga B. pennata and in fish oils. Its chemical composition is similar to eicosapentaenoic acid (EPA), except that a carbon is extended at the carboxy terminus, placing the first double bond at the δ6 position. HPA can be used to study the importance of double bond position in omega-3 fatty acids. It incorporates phospholipids and triacylglycerols in vivo with the same efficiency as EPA and docosahexaenoic acid, and exhibits a strong inhibitory effect on the synthesis of arachidonic acid from linoleic acid. HPA is a poor substrate for prostaglandin H synthase (PGHS) (cyclooxygenase) and 5-lipoxygenase, but retains the ability to rapidly inactivate PGHS.

HY-W251428

Phosphatidylglycerols (egg) (sodium salt)

Biochemical Assay Reagents

Phosphatidylglycerol is a naturally occurring anionic phospholipid that is a component of plant, animal and bacterial cell membranes. It is present in prokaryotes and eukaryotes less than phosphatidylethanolamine, and in eukaryotes less than phosphatidylcholine. It is formed by the reaction between CDP-diglyceride and L-α-glycerol 3-phosphate followed by dephosphorylation and is the metabolic precursor of cardiolipin. Phosphatidylglycerols containing polyunsaturated and monounsaturated fatty acyl chains inhibit and promote the proliferation of murine keratinocytes, respectively. Phosphatidylglycerol is the second-largest lipid component of mammalian lung surfactant, accounting for 10% of lipids, and has reduced levels of pulmonary surfactant in infants with respiratory distress syndrome. Phosphatidylglycerol (egg) is a mixture of phosphatidylglycerols isolated from eggs with various fatty acyl groups at the sn-1 and sn-2 positions. References: [1]. Ohtsuka, T., Nishijima, M., and Akamatsu, Y. Phosphatidylglycerol phosphate synthase-deficient somatic mutants with impaired phosphatidylglycerol and cardiolipin biosynthesis J. Biol. Chemical. 268(30), 22908-22913 (1993).[2]. Furse, S. Are phosphatidylglycerols essential for terrestrial life J. Chemistry. biology. 10(1), 1-9 (2016).[3]. Xie, D., Seremwe, M., Edwards, JG, et al. Different effects of different phosphatidylglycerols on the proliferation of mouse keratinocytes PLoS One 9(9), e107119 (2014).

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

Cat. No.	Product Name	Target	Research Area

HY-P1113A

*Phospho-Glycogen Synthase* Peptide-2(substrate) TFA**	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .

HY-P5352

Hyaluronan-IN-1	Peptides	Others
Hyaluronan-IN-1 is a biological active peptide. (This 12 amino acids peptide is a hyaluronan inhibitor (HA), a high molecular weight glycosaminoglycan expressed abundantly in the extracellular matrix and on cell surfaces. This peptide shows specific binding to soluble, immobilized, and cell-associated forms of HA, and it inhibits leukocyte adhesion to HA substrates almost completely.)

HY-P5351

Hyaluronan-binding peptide, biotin labeled	Peptides	Others
Hyaluronan-binding peptide, biotin labeled is a biological active peptide. (This peptide is a hyaluronan-binding peptide biotinylated through a C-terminal GGGSK linker. Hyaluronan (HA) is a nonsulfated glycosaminoglycan expressed in the extracellular matrix and on cell surfaces. HA plays a role in fertilization, embryonic development, wound healing, angiogenesis, leukocyte trafficking to inflamed tissues, and cancer metastasis. This peptide has been shown to block HA binding to CD44 receptors and inhibit T cell proliferation.)

HY-P2739

Citrate synthase	Peptides	Others
Citrate synthase is responsible for catalyzing the first reaction of the citric acid cycle: the condensation of acetyl-CoA and oxaloacetate to form citrate. Citrate synthase is localized within eukaryotic cells in the mitochondrial matrix .

HY-P1113

*Phospho-Glycogen Synthase* Peptide-2(substrate)**	GSK-3	Others
Phospho-Glycogen Synthase Peptide-2 (substrate) is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used for affinity purification of protein-serine kinases .

HY-P3741

*[Ala9,10, Lys11,12] Glycogen Synthase* (1-12)**	PKC	Neurological Disease
[Ala9,10, Lys11,12] Glycogen Synthase (1-12) is a selective substrate for phosphorylation by protein kinase C (PKC). [Ala9,10, Lys11,12] Glycogen Synthase (1-12) can be used to determine the activity of protein kinase C .

HY-P3519

ACV Tripeptide	Peptides	Others
ACV Tripeptide is a key biosynthetic precursor of penicillin and cephalosporins and is found in Penicillium chrysogenum and Acremonium chrysogenum. ACV Tripeptide is synthesized by a large non-ribosomal peptide synthase called ACV synthase, which is encoded by the 11 kb The pchAB gene encodes this enzyme .

HY-P2558

GSK3 Substrate, α, β subunit

GSK-3 Others

GSK3 Substrate, α, β subunit is peptide substrate for glycogen synthase kinase-3 (GSK-3) and can be used to measure GSK-3 activity .

HY-W142119

α-Methyl-DL-aspartic acid	Peptides	Neurological Disease
α-Methyl-DL-aspartic acid is a specific inhibitor of argininosuccinate synthase (ASS), and also is the rate-limiting enzyme for the recycling of 1-citrulline to 1-arginine .

HY-W142014

N,O-Didansyl-L-tyrosine cyclohexylammonium	Thymidylate Synthase	Cancer
N,O-Didansyl-L-tyrosine cyclohexylammonium is a potent selective thymidylate synthase (TS) inhibitor, acts on TS of Escherichia coli, Lactobacillus casei and human with the IC₅₀ values of 5.0, 3.4 and 119 μM, respectively .

HY-P3713

Presenilin 1 (349-361)	Peptides	Cancer
Presenilin 1 (349-361) is an active petide, and synthetic peptides representing amino acids 349–361 can be phosphorylated by glycogen synthase kinase-3β(GSK3β) in vitro. Presenilin 1 (349-361) can be used for the research of various diseases .

HY-P0315

Crosstide

1 Publications Verification

Akt Others

Crosstide is a peptide analog of glycogen synthase kinase α/β fusion protein sequence which is a substrate for Akt.

HY-134141

5-Octyl hydrogen L-glutamate	Peptides	Metabolic Disease
5-Octyl hydrogen L-glutamate is cell-permeable molecule and can be used for synthesizing 5-octyl ester derivatives (5-octyl α-ketoglutarate) .

HY-P0184A

Camstatin TFA	NO Synthase	Neurological Disease
Camstatin TFA, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase .

HY-P1114

2B-(SP)	GSK-3	Neurological Disease
2B-(SP) is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-P1114A

2B-(SP) (TFA)	GSK-3	Cancer
2B-(SP) TFA is a eIF2B-based substrate for glycogen synthase kinase-3 (GSK-3). 2B-(SP) TFA is readily phosphorylated by both the α and β isoforms of GSK-3 .

HY-P5526

CCK1-specific peptide substrate	Peptides	Others
CCK1-specific peptide substrate is a biological active peptide. (This peptide sequence is based on rabbit muscle glycogen synthase with Ser7 phosphorylated. It is a peptide substrate for Casein Kinase I (CK1). CK1 phosphorylates Ser10. Ser7 is phosphorylated by PKA in vivo.)

HY-P0316

TP508	Thrombin NO Synthase	Cardiovascular Disease
TP508 is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 activates endothelial *NO synthase* (eNOS)** and stimulates production of NO in human endothelial cells. TP508 activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P0316A

TP508 TFA	Thrombin NO Synthase	Cardiovascular Disease
TP508 TFA is a 23-amino acid nonproteolytic thrombin peptide that represents a portion of the receptor-binding domain of thrombin molecule. TP508 TFA activates endothelial *NO synthase* (eNOS)** and stimulates production of NO in human endothelial cells. TP508 TFA activates endothelial cells and stem cells to revascularize and regenerate tissues .

HY-P3906

Melittin free acid	Fungal Apoptosis Phospholipase Reactive Oxygen Species	Infection
Melittin free acid is a basic 26-amino-acid polypeptide, the major active ingredient of honeybee venom. Melittin free acid is an activator of phospholipase A2 (PLA2). Melittin free acid has broad-spectrum antifungal activity with MIC values of 0.4-60 μM. Melittin free acid hinders fungal growth by inducing cell apoptosis, repressing (1,3)-β-D-glucan synthase and participating in other pathways .

HY-P0117A

Tat-NR2B9c TFA Maximum Cited Publications 7 Publications Verification Tat-NR2Bct TFA; NA-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0117

Tat-NR2B9c Maximum Cited Publications 7 Publications Verification Tat-NR2Bct; NA-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

Species:	Human (65) Mouse (6) Bovine (1) Rat (1) E.coli (5)
Tag:	His (75) SUMO (9) Tag Free (5) Myc (4) GST (2) MBP (1) Fc (1) Flag (3)
Source:	HEK293 (19) E. coli Cell-free (7) Sf9 insect cells (11) P. pastoris (2) E. coli (46)

Cat. No.	Compare	Product Name	Species	Source

HY-P72222

	HAS2 Protein, Mouse (His) Has2; Hyaluronan synthase 2; EC 2.4.1.212; Hyaluronate synthase 2; Hyaluronic acid synthase 2; HA synthase 2	Mouse	E. coli
	The HAS2 protein adds GlcNAc or GlcUA monosaccharides to hyaluronic acid, playing a crucial role in its synthesis. HAS2 Protein, Mouse (His) is the recombinant mouse-derived HAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of HAS2 Protein, Mouse (His) is 308 a.a., with molecular weight of ~39.9 kDa.

HY-P70959

	NANS Protein, Human (His) Sialic Acid synthase; N-Acetylneuraminate synthase; N-Acetylneuraminate-9-Phosphate synthase; N-Acetylneuraminic Acid Phosphate synthase; N-Acetylneuraminic Acid synthase; NANS; SAS	Human	E. coli
	NANS Protein is an enzyme that functions in the biosynthetic pathways of sialic acids. NANS protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively. NANS Protein, Human (His) is the recombinant human-derived NANS protein, expressed by E. coli , with N-6*His labeled tag. The total length of NANS Protein, Human (His) is 359 a.a., with molecular weight of ~42.0 kDa.

HY-P79168

Hyaluronan Lyase Protein, S. agActiae (His)

Hyaluronidase; SAG1197
Others E. coli

HY-P70038

	*Deoxyhypusine synthase/DHS Protein, Human (His)* rHuDeoxyhypusine synthase/DHS, His; Deoxyhypusine synthase; DHS; DHPS; DS	Human	E. coli
	The deoxyhorseuridine synthase (DHS) protein plays a crucial role in the NAD-dependent oxidative cleavage of spermidine, followed by the transfer of the butylamine moiety of spermidine to the ε-amino group of the eIF-5A precursor protein. On the key lysine. Deoxyhypusine synthase/DHS Protein, Human (His) is the recombinant human-derived Deoxyhypusine synthase/DHS protein, expressed by E. coli , with C-6*His labeled tag. The total length of Deoxyhypusine synthase/DHS Protein, Human (His) is 369 a.a., with molecular weight of ~44.52 kDa.

HY-P74251

	*Citrate Synthase/CS Protein, Human (sf9, His)* Citrate synthase, mitochondrial; Citrate (Si)-synthase; CS	Human	Sf9 insect cells
	Citrate Synthase (CS) is a key enzyme in carbohydrate metabolism, specifically in the tricarboxylic acid (TCA) cycle, where it catalyzes the conversion of oxaloacetate and acetyl-CoA to form citrate. This enzymatic process represents the first and crucial step in the TCA cycle, which is fundamental to cellular energy production. By initiating the cycle and facilitating the condensation of acetyl-CoA with oxaloacetate, CS plays a central role in channeling metabolic intermediates towards the production of energy-rich molecules. This step not only generates citrate but also sets the stage for subsequent reactions in the TCA cycle, ultimately contributing to the efficient extraction of energy from carbohydrates and other metabolic substrates. The activity of CS is pivotal in maintaining cellular energy homeostasis and ensuring the proper functioning of aerobic metabolism. Citrate Synthase/CS Protein, Human (sf9, His) is the recombinant human-derived Citrate Synthase/CS protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Citrate Synthase/CS Protein, Human (sf9, His) is 439 a.a., with molecular weight of ~46 kDa.

HY-P70224

	GGPS1 Protein, Human (His) rHuGeranylgeranyl pyrophosphate synthase/GGPS1, His; Geranylgeranyl Pyrophosphate synthase; GGPP synthase; GGPPSase; (2E; 6E)-Farnesyl Diphosphate synthase; Dimethylallyltranstransferase; Farnesyl Diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl Diphosphate synthase; Geranyltranstransferase; GGPS1	Human	E. coli
	The GGPS1 protein is responsible for catalyzing the trans-addition of three molecules of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP) to synthesize geranylgeranyl pyrophosphate. This compound is an important precursor for the biosynthesis of carotenoids and geranylated proteins. GGPS1 Protein, Human (His) is the recombinant human-derived GGPS1 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GGPS1 Protein, Human (His) is 300 a.a., with molecular weight of ~35.0 kDa.

HY-P702577

	GGPS1 Protein, Human (HEK293, His) rHuGeranylgeranyl pyrophosphate synthase/GGPS1, His; Geranylgeranyl Pyrophosphate synthase; GGPP synthase; GGPPSase; (2E; 6E)-Farnesyl Diphosphate synthase; Dimethylallyltranstransferase; Farnesyl Diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl Diphosphate synthase; Geranyltranstransferase; GGPS1	Human	HEK293

HY-P71098

	*Tryptophan Synthase* Protein, E.coli (His)** Tryptophan synthetase; Tryptophan synthase	E.coli	E. coli
	The TrpA protein, especially its α subunit, plays a crucial role in catalyzing the aldol cleavage of indole glycerol phosphate to produce indole and glyceraldehyde 3-phosphate. This enzymatic activity highlights the importance of TrpA in the tryptophan biosynthetic pathway, providing an essential component of cellular processes. Tryptophan Synthase Protein, E.coli (His) is a recombinant protein dimer complex containing E. coli-derived Tryptophan Synthase protein, expressed by E. coli , with N-6*His labeled tag. Tryptophan Synthase Protein, E.coli (His), has molecular weight of 28 & 40-50 kDa, respectively.

HY-P73684

	PTS Protein, Human (His) 6-pyruvoyl tetrahydrobiopterin synthase; PTP synthase; PTPS; PTS	Human	E. coli
	PTS proteins are critical in the biosynthesis of tetrahydrobiopterin, an important cofactor for aromatic amino acid hydroxylase. It catalyzes the conversion of 7,8-dihydroneopterin triphosphate to 6-pyruvoyltetrahydropterin, a key step in the biosynthetic pathway. PTS Protein, Human (His) is the recombinant human-derived PTS protein, expressed by E. coli , with N-His labeled tag. The total length of PTS Protein, Human (His) is 145 a.a., with molecular weight of ~17 kDa.

HY-P75197

	FDPS Protein, Human (His) Farnesyl pyrophosphate synthase; FPP synthase; FPS; KIAA1293	Human	E. coli
	FDPS Protein, a key enzyme in isoprenoid biosynthesis, catalyzes the formation of farnesyl diphosphate (FPP). FPP is a precursor for essential metabolites like sterols, dolichols, carotenoids, and ubiquinones. It also serves as a substrate for protein farnesylation and geranylgeranylation. FDPS sequentially condenses isopentenyl pyrophosphate with dimethylallyl pyrophosphate and then with geranylpyrophosphate to produce farnesyl pyrophosphate. FDPS Protein, Human (His) is the recombinant human-derived FDPS protein, expressed by E. coli , with N-His labeled tag. The total length of FDPS Protein, Human (His) is 353 a.a., with molecular weight of ~41 kDa.

HY-P78950

	ALAS2 Protein, Human (His) 5-aminolevulinate synthase, erythroid-specific, mitochondrial; ALAS-E; 5-aminolevulinic acid synthase 2; ALASE; ASB	Human	E. coli
	ALAS2 Protein catalyzes PLP-dependent condensation of succinyl-CoA and glycine, producing aminolevulinic acid (ALA) with CoA and CO2 by-products. It significantly contributes to heme formation in erythropoiesis, with catalytic activity reaching 75-85% of isoform 1. ALAS2 Protein, Human (His) is the recombinant human-derived ALAS2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ALAS2 Protein, Human (His) is 538 a.a., with molecular weight of ~63.5 kDa.

HY-P70832

	HABP2 Protein, Human (HEK293, His) 2 Publications Verification Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma Hyaluronan-binding protein	Human	HEK293
	HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HABP2 Protein, Human (HEK293, His) is 256 a.a., with molecular weight of 35-40 kDa.

HY-P72309

	*Lanosterol synthase/LSS Protein, Human (P.pastoris, His)* OSCLanosterol synthase; Oxidosqualene--lanosterol cyclase; OSC	Human	P. pastoris
	LSS protein, a pivotal enzyme in cholesterol biosynthesis, catalyzes the cyclization of (S)-2,3 oxidosqualene into lanosterol, a crucial step in sterol nucleus formation. Beyond cholesterol biosynthesis, LSS may regulate lens protein aggregation, maintaining lens transparency. LSS's enzymatic action impacts fundamental and specialized cellular processes, underscoring its significance in diverse physiological contexts. Lanosterol synthase/LSS Protein, Human (P.pastoris, His) is the recombinant human-derived Lanosterol synthase/LSS protein, expressed by P. pastoris , with N-His labeled tag. The total length of Lanosterol synthase/LSS Protein, Human (P.pastoris, His) is 731 a.a., with molecular weight of ~86.0 kDa.

HY-P75196

	FDPS Protein, Mouse (His) Farnesyl pyrophosphate synthase; FPP synthase; CR 39; Fdps	Mouse	E. coli
	FDPS proteins are key enzymes in isoprenoid biosynthesis and play a crucial role in the formation of farnesyl diphosphate (FPP). FPP is a precursor of essential metabolites involved in protein farnesylation and geranylgeranylation. FDPS Protein, Mouse (His) is the recombinant mouse-derived FDPS protein, expressed by E. coli , with N-His labeled tag. The total length of FDPS Protein, Mouse (His) is 353 a.a., with molecular weight of ~42.8 kDa.

HY-P701983

	metK Protein, Shigella sonnei (His) metK; S-adenosylmethionine synthase; AdoMet synthase; MAT; Methionine adenosyltransferase	Others	E. coli
	The metK protein plays a crucial role in cellular processes by catalyzing the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. This enzymatic activity involves a two-step process, first synthesizing AdoMet and then hydrolyzing tripolyphosphate. metK Protein, Shigella sonnei (His) is the recombinant metK protein, expressed by E. coli , with N-6*His labeled tag. The total length of metK Protein, Shigella sonnei (His) is 384 a.a., .

HY-P76843

	COASY Protein, Human (His) Bifunctional coenzyme A synthase; CoA synthase; NBP; POV-2; PPAT; DPCK	Human	E. coli
	COASY Protein, a bifunctional enzyme, plays a pivotal role in catalyzing the fourth and fifth steps of the CoA biosynthetic pathway. The coaD domain facilitates phosphopantetheine adenylyltransferase activity for the fourth reaction, and the coaE domain drives dephospho-CoA kinase activity for the fifth reaction. COASY is crucial for regulating CoA biosynthesis, ensuring efficient synthesis of the vital cofactor involved in diverse cellular metabolic pathways. COASY Protein, Human (His) is the recombinant human-derived COASY protein, expressed by E. coli, with N-His labeled tag. The total length of COASY Protein, Human (His) is 269 a.a., with molecular weight of ~33 kDa.

HY-P73632

	*Sphingomyelin Synthase* 2/SGMS2 Protein, Human (HEK293, Fc)** Phosphatidylcholine:ceramide cholinephosphotransferase 2; Sphingomyelin synthase 2; SGMS2; SMS2	Human	HEK293
	The sphingomyelin synthase 2 (SGMS2) protein plays a crucial role in plasma membrane sphingomyelin synthesis. It catalyzes the reversible transfer of the phosphocholine moiety in sphingomyelin biosynthesis to form ceramide phosphocholine. Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is the recombinant human-derived Sphingomyelin Synthase 2/SGMS2 protein, expressed by HEK293 , with N-mFc labeled tag. The total length of Sphingomyelin Synthase 2/SGMS2 Protein, Human (HEK293, Fc) is 79 a.a., with molecular weight of ~35.7 kDa.

HY-P71242

	PTGDS Protein, Human (HEK293, His) 1 Publications Verification Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD synthase; Lipocalin-Type Prostaglandin-D synthase; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PTGDS Protein, Human (HEK293, His) is 168 a.a., with molecular weight of 20-29 kDa.

HY-P70269A

	HMBS/Porphobilinogen deaminase Protein, Human (N-His) Porphobilinogen deaminase; PBG-D; Hydroxymethylbilane synthase (HMBS); Pre-uroporphyrinogen synthase	Human	E. coli
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (N-His) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by E. coli , with N-6*His labeled tag. The total length of HMBS/Porphobilinogen deaminase Protein, Human (N-His) is 360 a.a., with molecular weight of ~40 kDa.

HY-P702418

	PTGES Protein, Mouse (Cell-Free, His, SUMO) Microsomal prostaglandin E synthase 1 mPGES-1; Pges	Mouse	E. coli Cell-free
	PTGES proteins act as terminal enzymes in COX-2-mediated PGE2 biosynthesis and regulate inflammation, fever, and pain. In response to inflammatory stimuli, PTGES catalyzes the glutathione-dependent redox of PGH2 to PGE2. PTGES Protein, Mouse (Cell-Free, His, SUMO) is the recombinant mouse-derived PTGES protein, expressed by E. coli Cell-free , with N-10*His, N-SUMO labeled tag. The total length of PTGES Protein, Mouse (Cell-Free, His, SUMO) is 153 a.a., with molecular weight of 35.8 kDa.

HY-P71242A

	PTGDS Protein, Human (HEK293, C-His) Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD synthase; Lipocalin-Type Prostaglandin-D synthase; Prostaglandin-D2 synthase; PGD2 synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein serves a multifaceted role in various physiological processes. It catalyzes the conversion of PGH2 to PGD2, a prostaglandin with implications in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Beyond its involvement in these vascular functions, PTGDS plays a crucial role in diverse central nervous system (CNS) activities, including sedation, NREM sleep, and PGE2-induced allodynia, and may exhibit an anti-apoptotic function in oligodendrocytes. Notably, PTGDS has a broad substrate-binding capacity, interacting with small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid, and thyroid hormone. This suggests its potential role as a scavenger for harmful hydrophobic molecules and as a transporter for secretory retinoids and thyroid hormones. Additionally, PTGDS is implicated in the development and maintenance of various blood barriers, including the blood-brain, blood-retina, blood-aqueous humor, and blood-testis barriers, indicating its significance in barrier function. Furthermore, it plays essential roles in the maturation and maintenance of the central nervous system and the male reproductive system, as well as participates in PLA2G3-dependent maturation of mast cells, further emphasizing its intricate involvement in diverse biological processes. PTGDS Protein, Human (HEK293, C-His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTGDS Protein, Human (HEK293, C-His) is 168 a.a., with molecular weight of ~21 kDa.

HY-P72098

	ATP5D Protein, Human (His) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-10*His labeled tag. The total length of ATP5D Protein, Human (His) is 146 a.a., with molecular weight of ~20 kDa.

HY-P74222

	COX-2 Protein, Human (sf9, His) Prostaglandin G/H synthase 2; COX-2; PGHS-2	Human	Sf9 insect cells
	COX-2 protein is involved in the alternative pathway of prostaglandin biosynthesis. COX-2 Protein, Human (sf9, His) is the recombinant human-derived COX-2 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of COX-2 Protein, Human (sf9, His) is 604 a.a., with molecular weight of ~66 kDa.

HY-P75919

	LTC4S Protein, Human (sf9, His) Leukotriene C4 synthase; LTC4 synthase; LTC4S	Human	Sf9 insect cells
	LTC4S plays a crucial role in cellular processes by catalyzing the conjugation of leukotriene A4 with reduced glutathione (GSH), yielding the bioactive lipid mediator leukotriene C4 with remarkable specificity. This enzymatic activity is pivotal in the regulation of inflammation and immune responses. Additionally, LTC4S demonstrates versatility by facilitating the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid, resulting in the formation of maresin conjugate in tissue regeneration 1 (MCTR1). Notably, MCTR1 possesses potent anti-inflammatory and proresolving actions, emphasizing the multifaceted nature of LTC4S in mediating lipid metabolism and inflammation. LTC4S Protein, Human (sf9, His) is the recombinant human-derived LTC4S protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of LTC4S Protein, Human (sf9, His) is 150 a.a., with molecular weight of ~17 kDa.

HY-P72097

	ATP5D Protein, Human (His-SUMO) ATP synthase subunit delta; mitochondrial ; ATP synthase subunit delta; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; delta subunit; ATP5D; ATPD_HUMAN; F ATPase delta subunit ; F-ATPase delta subunit; Mitochondrial ATP synthase complex delta subunit precusor ; Mitochondrial ATP synthase delta subunit	Human	E. coli
	ATP5D Protein, a vital component of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. As part of the F(1) domain and central stalk, ATP5D contributes to ATP hydrolysis through a rotary mechanism. The ATP synthase complex, involving ATP5D, is pivotal for cellular energy production via ATP synthesis. ATP5D Protein, Human (His-SUMO) is the recombinant human-derived ATP5D protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag. The total length of ATP5D Protein, Human (His-SUMO) is 146 a.a., with molecular weight of ~31 kDa.

HY-P702220

	ATP5J2 Protein, Human (Cell-Free, His) ATP synthase subunit f, mitochondrial; ATP synthase membrane subunit f	Human	E. coli Cell-free
	ATP5J2 protein is a component of mitochondrial membrane ATP synthase (complex V), which uses the proton gradient established by the respiratory chain electron transport complex to help ADP synthesize ATP. ATP5J2 is located in the F(0) domain as a small subunit and cooperates with subunit a in the membrane. ATP5J2 Protein, Human (Cell-Free, His) is the recombinant human-derived ATP5J2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of ATP5J2 Protein, Human (Cell-Free, His) is 94 a.a., with molecular weight of 12.4 kDa.

HY-P72337

	cGAS Protein, Human (His) 1 Publications Verification Cyclic GMP-AMP synthase; cGAMP synthase; h-cGAS; 2'3'-cGAMP synthase; Mab-21 domain-containing protein 1; MB21D1; C6orf150	Human	E. coli
	The cGAS protein is a nucleotidyl transferase that crucially mediates innate immunity by catalyzing the formation of 2',3'-cGAMP from ATP and GTP upon binding to double-stranded DNA (dsDNA). As a DNA sensor, cGAS detects exogenous and endogenous DNA, triggering STING1 activation and type I interferon production. cGAS Protein, Human (His) is the recombinant human-derived cGAS protein, expressed by E. coli , with C-6*His labeled tag. The total length of cGAS Protein, Human (His) is 522 a.a., with molecular weight of ~58.9 kDa.

HY-P71445

	CPS1/CPSase I Protein, Human (His) Carbamoyl phosphate synthase; Carbamoyl phosphate synthase mitochondrial; Carbamoyl phosphate synthase; Carbamoyl phosphate synthetase 1; Carbamoyl phosphate synthetase 1 mitochondrial; Carbamoyl phosphate synthetase I; Carbamoyl-phosphate synthase [ammonia]; Carbamoyl-phosphate synthetase I; Carbamoylphosphate synthase; Carbamoylphosphate synthetase 1; Carbamoylphosphate synthetase I; CPS 1; Cps1; CPSase 1; CPSase I; CPSASE1; mitochondrial; MS738	Human	E. coli
	The CPS1/CPSase I protein is critical in participating in the urea cycle and is essential for the elimination of excess ammonia in urea-bearing animals. This essential enzyme converts toxic ammonia (a byproduct of amino acid catabolism) into urea, promoting safe excretion. CPS1/CPSase I Protein, Human (His) is the recombinant human-derived CPS1/CPSase I protein, expressed by E. coli , with N-His labeled tag. The total length of CPS1/CPSase I Protein, Human (His) is 147 a.a., with molecular weight of ~20.5 kDa.

HY-P71036

	HPGDS Protein, Human Glutathione-Dependent PGD synthase; Glutathione-Requiring Prostaglandin D synthase; Prostaglandin-H2 D-Isomerase; HPGDS; GSTS; PGDS; PTGDS2	Human	E. coli
	HPGDS protein is a multifunctional enzyme with bifunctionality, and its C-terminal and N-terminal domains have different activities. The C terminus acts as an epoxide hydrolase, promoting xenobiotic metabolism by degrading harmful epoxides and regulating physiological mediator levels. HPGDS Protein, Human is the recombinant human-derived HPGDS protein, expressed by E. coli , with tag free. The total length of HPGDS Protein, Human is 199 a.a., with molecular weight of ~26.0 kDa.

HY-P71097

	TrpA Protein, E.coli Tryptophan synthase alpha chain; trpA;	E.coli	E. coli
	The TrpA protein, especially its α subunit, plays a crucial role in catalyzing the aldol cleavage of indole glycerol phosphate to produce indole and glyceraldehyde 3-phosphate. This enzymatic activity highlights the importance of TrpA in the tryptophan biosynthetic pathway, providing an essential component of cellular processes. TrpA Protein, E.coli is the recombinant E. coli-derived TrpA protein, expressed by E. coli , with tag free. The total length of TrpA Protein, E.coli is 268 a.a., with molecular weight of ~26 kDa.

HY-P72070

	ACLY Protein, Human (His-SUMO) ACL; Acly; ACLY_HUMAN; ATP citrate pro-S; lyase; ATP citrate lyase; ATP citrate synthase; ATP-citrate pro-S-; -lyase; ATP-citrate synthase; ATPcitrate synthase; ATPCL; Citrate cleavage enzyme; CLATP; OTTHUMP00000164773	Human	E. coli
	ACLY Protein, Human (His-SUMO) is an important enzyme in the cholesterol biosynthetic pathway. ACLY produces acetyl-CoA (AcCoA) from mitochondrial citrate for cholesterol and fatty acid biosynthesis.

HY-P72118

	CBS Protein, Human (His) AI047524; AI303044; Beta thionase; Beta-thionase; Cbs; Cbs cystathionine beta-synthase; CBS_HUMAN; Cystathionine beta synthase; Cystathionine beta-synthase; EC 4.2.1.22; HIP 4; HIP4; Methylcysteine synthase; MGC18856; MGC18895; MGC37300; OTTHUMP00000109416; OTTHUMP00000109418; Serine sulfhydrase	Human	E. coli
	CBS, a hydro-lyase, initiates the transsulfuration pathway by catalyzing the beta-replacement reaction, converting L-serine to L-cystathionine using L-homocysteine. This process eliminates L-methionine and the potentially harmful metabolite L-homocysteine. CBS, beyond its catabolic role, contributes to hydrogen sulfide production, serving as a gasotransmitter with signaling and cytoprotective effects, particularly on neurons. CBS Protein, Human (His) is the recombinant human-derived CBS protein, expressed by E. coli , with N-6*His labeled tag. The total length of CBS Protein, Human (His) is 550 a.a., with molecular weight of ~64.5 kDa.

HY-P71458

	PpsA Protein, E.coli (His-SUMO) ppsA; pps; b1702; JW1692Phosphoenolpyruvate synthase; PEP synthase; EC 2.7.9.2; Pyruvate; water dikinase	E.coli	E. coli
	The PpsA protein plays a crucial role in cellular metabolism by catalyzing the conversion of pyruvate to phosphoenolpyruvate, a key step in glycolysis and gluconeogenesis. This enzyme activity is the basis for the interconversion of metabolic intermediates and contributes to the regulation of intracellular energy production and utilization. PpsA Protein, E.coli (His-SUMO) is the recombinant E. coli-derived PpsA protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of PpsA Protein, E.coli (His-SUMO) is 791 a.a., with molecular weight of ~103.3 kDa.

HY-P71099

	TrpB Protein, E.coli (His) Tryptophan synthase beta chain; trpB	E.coli	E. coli
	The TrpB protein, especially its β subunit, plays a crucial role in the synthesis of L-tryptophan from indole and L-serine. This enzyme function involves converting precursor molecules into the essential amino acid L-tryptophan, thereby facilitating its biosynthetic pathway. TrpB Protein, E.coli (His) is the recombinant E. coli-derived TrpB protein, expressed by E. coli , with N-6*His labeled tag. The total length of TrpB Protein, E.coli (His) is 396 a.a., with molecular weight of 40-50 kDa.

HY-P76379

	HAPLN1 Protein, Human (HEK293, His) Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; HAPLN1; CRTL1	Human	HEK293
	HAPLN1 protein is vital in stabilizing proteoglycan monomer aggregates in cartilage's extracellular matrix. Through interaction with hyaluronic acid, it ensures structural integrity and stability, facilitating proteoglycan binding and organization. HAPLN1's role is crucial for maintaining the extracellular environment, providing proper support and resilience in cartilage tissues. HAPLN1 Protein, Human (HEK293, His) is the recombinant human-derived HAPLN1 protein, expressed by HEK293 , with C-His labeled tag. The total length of HAPLN1 Protein, Human (HEK293, His) is 339 a.a., with molecular weight of ~52 KDa.

HY-P70269

	HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His) rHuPorphobilinogen deaminase/HMBS, His; Porphobilinogen Deaminase; PBG-D; Hydroxymethylbilane synthase; HMBS; Pre-Uroporphyrinogen synthase; HMBS; PBGD; UPS	Human	HEK293
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His) is 360 a.a., with molecular weight of ~47.0 kDa.

HY-P71550

	ATP5MG Protein, Bovine (Myc, His) ATP5MG; ATP5LATP synthase subunit g; mitochondrial; ATPase subunit g; ATP synthase membrane subunit g	Bovine	E. coli
	ATP5MG Protein, an essential part of mitochondrial membrane ATP synthase (Complex V), facilitates ATP generation from ADP using the proton gradient established by respiratory chain electron transport complexes. Positioned within the F(0) domain as a minor subunit alongside subunit a, ATP5MG collaborates with various subunits in the overall F-type ATPase complex, including CF(1) and CF(0), to ensure efficient ATP synthesis. ATP5MG Protein, Bovine (Myc, His) is the recombinant bovine-derived ATP5MG protein, expressed by E. coli , with N-His, C-Myc labeled tag. The total length of ATP5MG Protein, Bovine (Myc, His) is 102 a.a., with molecular weight of ~18.7 kDa.

HY-P71616

	FLAD1 Protein, Human (His-SUMO) FLAD1; PP591FAD synthase; EC 2.7.7.2; FAD pyrophosphorylase; FMN adenylyltransferase; Flavin adenine dinucleotide synthase	Human	E. coli
	The FLAD1 protein plays a key role in cellular processes involving small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA). It catalyzes two consecutive methylation steps that are necessary to convert the 7-monomethylguanosine (m(7)G) cap of these RNAs into 2,2,7-trimethylguanosine (m(2, 2,7)G) Cap structure is critical. FLAD1 Protein, Human (His-SUMO) is the recombinant human-derived FLAD1 protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of FLAD1 Protein, Human (His-SUMO) is 490 a.a., with molecular weight of ~70.2 kDa.

HY-P702485

	UGCG Protein, Human (Cell-Free, His) Ceramide glucosyltransferase; GLCT-1; Glucosylceramide synthase; GCS; Glycosylceramide synthase; UDP-glucose ceramide glucosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase	Human	E. coli Cell-free
	UGCG proteins play a key role in the glucosphingolipid (GSL) synthesis pathway based on glucosylceramide in the Golgi apparatus, catalyzing the key step of transferring glucose to ceramide to form glucosylceramide (GlcCer). GSLs have effects on membrane microdomains, affecting processes such as membrane trafficking and signal transduction. UGCG Protein, Human (Cell-Free, His) is the recombinant human-derived UGCG protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGCG Protein, Human (Cell-Free, His) is 394 a.a., with molecular weight of 47.7 kDa.

HY-P70269Y

	HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His, solution) rHuPorphobilinogen deaminase/HMBS, His; Porphobilinogen Deaminase; PBG-D; Hydroxymethylbilane synthase; HMBS; Pre-Uroporphyrinogen synthase; HMBS; PBGD; UPS	Human	HEK293
	HMBS (porphobilinogen deaminase) is key to heme biosynthesis, catalyzing the sequential polymerization of four porphobilinogen molecules to form hydroxymethylbiphenyl. The process begins with dipyrromethane cofactor assembly derived from porphobilinogen or preuroporphyrinogen and promoted by apoenzymes. HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His, solution) is the recombinant human-derived HMBS/Porphobilinogen deaminase protein, expressed by HEK293 , with C-6*His labeled tag. The total length of HMBS/Porphobilinogen deaminase Protein, Human (HEK293, His, solution) is 360 a.a., with molecular weight of ~47.0 kDa.

HY-P702099

	treS Protein, Thermus thermophilus treS; Trehalose synthase; Maltose alpha-D-glucosyltransferase	Others	E. coli
	The treS protein plays a key role in carbohydrate metabolism by catalyzing the reversible interconversion of maltose and α,α-trehalose via transglucosylation. This enzyme activity is critical for the dynamic regulation of intracellular sugar utilization and storage. treS Protein, Thermus thermophilus is the recombinant treS protein, expressed by E. coli , with tag free. The total length of treS Protein, Thermus thermophilus is 963 a.a., .

HY-P702433

	SGMS1 Protein, Human (Cell-Free, His) Phosphatidylcholine:ceramide cholinephosphotransferase 1; Medulla oblongata-derived protein; Protein Mob; Sphingomyelin synthase 1; Transmembrane protein 23	Human	E. coli Cell-free
	The SGMS1 protein is a key sphingomyelin synthase located in the Golgi apparatus and promotes sphingomyelin biosynthesis by transferring the phosphocholine moiety. This reversible reaction involves the conversion of phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol. SGMS1 Protein, Human (Cell-Free, His) is the recombinant human-derived SGMS1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SGMS1 Protein, Human (Cell-Free, His) is 413 a.a., with molecular weight of 51.4 kDa.

HY-P71291

	SEPHS1 Protein, Human (HEK293, His) Selenide; water dikinase 1; Selenium donor protein 1; Selenophosphate synthase 1; SEPHS1; SELD; SPS; SPS1	Human	HEK293
	The SEPHS1 protein catalyzes the synthesis of selenophosphate, a key step in selenium metabolism involving the conversion of selenide and ATP. This enzyme activity is the basis for selenoprotein biosynthesis and effectively promotes the incorporation of selenium into selenocysteine. SEPHS1 Protein, Human (HEK293, His) is the recombinant human-derived SEPHS1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SEPHS1 Protein, Human (HEK293, His) is 392 a.a., with molecular weight of ~42.0 kDa.

HY-P72060A

	ACPS Protein, Streptococcus pyogenes serotype M28 (His) acpS; M28_Spy1523Holo-[acyl-carrier-protein] synthase; Holo-ACP synthase; EC 2.7.8.7; 4'-phosphopantetheinyl transferase AcpS	Others	E. coli
	ACPS, an essential enzyme in cellular processes, transfers the 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acyl-carrier-protein. ACPS Protein, Streptococcus pyogenes serotype M28 (His) is the recombinant ACPS protein, expressed by E. coli , with N-6*His labeled tag. The total length of ACPS Protein, Streptococcus pyogenes serotype M28 (His) is 118 a.a., with molecular weight of ~15 kDa.

HY-P701881

	FASN Protein, Human (Sf9) FASN; Fatty acid synthase; Type I fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Acyl-[acyl-carrier-protein] hydrolase	Human	Sf9 insect cells
	FASN (fatty acid synthase) is a multifunctional enzyme that is key to the de novo biosynthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA using NADPH. This multifunctional protein contains seven catalytic activities and has an acyl carrier protein (ACP) domain with a binding site for the prosthetic group 4'-phosphopantetheine. FASN Protein, Human (Sf9) is the recombinant human-derived FASN protein, expressed by Sf9 insect cells , with tag free. The total length of FASN Protein, Human (Sf9) is 416 a.a., .

HY-P701882

	FASN Protein, Human (Sf9, His) FASN; Fatty acid synthase; Type I fatty acid synthase; [Acyl-carrier-protein] S-acetyltransferase; [Acyl-carrier-protein] S-malonyltransferase; 3-oxoacyl-[acyl-carrier-protein] synthase; 3-oxoacyl-[acyl-carrier-protein] reductase; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Enoyl-[acyl-carrier-protein] reductase; Acyl-[acyl-carrier-protein] hydrolase	Human	Sf9 insect cells
	FASN (fatty acid synthase) is a multifunctional enzyme that is key to the de novo biosynthesis of long-chain saturated fatty acids from acetyl-CoA and malonyl-CoA using NADPH. This multifunctional protein contains seven catalytic activities and has an acyl carrier protein (ACP) domain with a binding site for the prosthetic group 4'-phosphopantetheine. FASN Protein, Human (Sf9, His) is the recombinant human-derived FASN protein, expressed by Sf9 insect cells , with N-8*His labeled tag. The total length of FASN Protein, Human (Sf9, His) is 416 a.a., .

HY-P72060

	ACPS Protein, Streptococcus pyogenes serotype M28 (Baculovirus, His-Myc) acpS; M28_Spy1523Holo-[acyl-carrier-protein] synthase; Holo-ACP synthase; EC 2.7.8.7; 4'-phosphopantetheinyl transferase AcpS	Others	Sf9 insect cells
	ACPS Protein, Streptococcus pyogenes serotype M28 (Baculovirus, His-Myc), a 4-phosphopantetheinyl transferase, activates two distinct acyl carrier proteins (ACPs) that are present in fatty acid synthase (FAS) systems FAS-I and FAS-II, the ACP-I domain and the mycobacterial ACP-II protein (ACPM), respectively.

HY-P702098

	treS Protein, Thermus thermophilus (FLAG, His) treS; Trehalose synthase; Maltose alpha-D-glucosyltransferase	Others	E. coli
	The treS protein plays a key role in carbohydrate metabolism by catalyzing the reversible interconversion of maltose and α,α-trehalose via transglucosylation. This enzyme activity is critical for the dynamic regulation of intracellular sugar utilization and storage. treS Protein, Thermus thermophilus (FLAG, His) is the recombinant treS protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of treS Protein, Thermus thermophilus (FLAG, His) is 963 a.a., .

HY-P72095

	ATP5F1A Protein, Human (His) ATP synthase alpha chain; ATP synthase alpha chain; mitochondrial; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle; ; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; alpha subunit; ATP5A; Atp5a1; ATP5AL2; ATPA_HUMAN; ATPM; hATP1; HEL-S-123m; MC5DN4; mitochondrial;	Human	E. coli
	ATP5F1A is an important component of mitochondrial ATP synthase (complex V) that coordinates ATP production from ADP by utilizing the transmembrane proton gradient. As part of the F-type ATPase, the α and β subunits of ATP5F1A form the catalytic core to achieve ATP hydrolysis. ATP5F1A Protein, Human (His) is the recombinant human-derived ATP5F1A protein, expressed by E. coli , with N-6*His labeled tag. The total length of ATP5F1A Protein, Human (His) is 510 a.a., with molecular weight of ~59.2 kDa.

HY-P7613

	ASS1 Protein, Human (His) rHuASS1, His; Argininosuccinate synthase; Citrulline--Aspartate Ligase; ASS1; ASS	Human	E. coli
	ASS1 Protein, Human (His) is a recombinant human Argininosuccinate synthase expressed in E. coli with a His tag. Argininosuccinate synthase is an enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate.

Cat. No.	Product Name	Chemical Structure

HY-125818S3

Cytidine-5'-triphosphate-13C9 dilithium

Cytidine-5'-triphosphate- ¹³C₉ (Cytidine triphosphate- ¹³C₉ dilithium; 5'-CTP- ¹³C₉) dilithium is ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-125818S6

Cytidine-5'-triphosphate-15N3 dilithium

Cytidine-5'-triphosphate- ¹⁵N₃ (Cytidine triphosphate- ¹⁵N₃ dilithium; 5'-CTP- ¹⁵N₃) dilithium is ¹⁵N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-125818S4

Cytidine-5'-triphosphate-d14 dilithium

Cytidine-5'-triphosphate-d₁₄ (Cytidine triphosphate-d₁₄ dilithium; 5'-CTP-d₁₄) dilithium is deuterium labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-125818S2

Cytidine-5'-triphosphate-13C,d1 dilithium

Cytidine-5'-triphosphate- ¹³C,d₁ (Cytidine triphosphate- ¹³C,d₁ dilithium; 5'-CTP- ¹³C,d₁) dilithium is deuterium and ¹³C-labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-D0145S

7-Ethoxyresorufin-d5
7-Ethoxyresorufin-d₅ is deuterium labeled 7-Ethoxyresorufin. 7-Ethoxyresorufin (Resorufin ethyl ether) is a fluorometric substrate and competitive inhibitor of cytochrome P450, especially CYP1A1. 7-Ethoxyresorufin also inhibits NO synthase[1][2].

HY-125818S5

Cytidine-5'-triphosphate-15N3,d14 dilithium

Cytidine-5'-triphosphate- ¹⁵N₃,d₁₄ (Cytidine triphosphate- ¹⁵N₃,d₁₄ dilithium; 5'-CTP- ¹⁵N₃,d₁₄) dilithium is deuterium and ¹⁵N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule?in the de novo?pyrimidine biosynthetic pathway in?T. gondii.

HY-101410S

SDMA-d6

SDMA-d₆ is the deuterium labeled SDMA. SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity[1][2].

HY-14885S

Eliglustat-d15 tartrate
Eliglustat-d₁₅ (tartrate) is the deuterium labeled Eliglustat. Eliglustat tartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

HY-14885S1

Eliglustat-d4

Eliglustat-d₄ is the deuterium labeled Eliglustat. Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM[1][2].

HY-110363

Miglustat-d9 hydrochloride
Miglustat-d₉ (hydrochloride) is the deuterium labeled Miglustat (hydrochloride). Miglustat hydrochloride is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1)[1][2].

HY-N0473S8

L-Tyrosine-d2

L-Tyrosine-d₂ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S9

L-Tyrosine-d7

L-Tyrosine-d₇ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S14

L-Tyrosine-d5

L-Tyrosine-d₅ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S15

L-Tyrosine-d3

L-Tyrosine-d₃ is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-113216S

Asymmetric dimethylarginine-d7 hydrochloride hydrate
Asymmetric dimethylarginine-d₇ (hydrochloride hydrate) is the deuterium labeled Asymmetric dimethylarginine. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a num

HY-N0473S1

L-Tyrosine-15N

L-Tyrosine- ¹⁵N is the ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-17020S

Miglustat-d9
Miglustat-d9 is the deuterium labeled Miglustat. Miglustat (N-Butyldeoxynojirimycin) is an inhibitor of glucosylceramide synthase, primarily to treat Type I Gaucher disease (GD1) .

HY-N0473S10

L-Tyrosine-d2-1

L-Tyrosine-d₂-1 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S12

L-Tyrosine-17O

L-Tyrosine- ¹⁷O is the ¹⁷O-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S4

L-Tyrosine-13C

L-Tyrosine- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S13

L-Tyrosine-d2-2

L-Tyrosine-d₂-2 is the deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S

L-Tyrosine-d4

L-Tyrosine-d₄ is a deuterium labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[1].
HY-N0473S2

L-Tyrosine-13C6

L-Tyrosine- ¹³C₆ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S3

L-Tyrosine-13C9

L-Tyrosine- ¹³C₉ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S5

L-Tyrosine-4-13C

L-Tyrosine-4- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S7

L-Tyrosine-1-13C

L-Tyrosine-1- ¹³C is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.
HY-N0473S6

L-Tyrosine-3,5-13C2

L-Tyrosine-3,5- ¹³C₂ is the ¹³C-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-113446S

Leukotriene C4-d5
Leukotriene C4-d₅ is the deuterium labeled Leukotriene C4. Leukotriene C4 is the parent cysteinyl leukotriene produced by the LTC4 synthase catalyzed conjugation of glutathione to LTA4.

HY-N0473S11

L-Tyrosine-15N,d7
L-Tyrosine- ¹⁵N,d₇ is the deuterium and ¹⁵N-labeled L-Tyrosine. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex.

HY-N0473S16

L-Tyrosine-13C,15N
L-Tyrosine- ¹³C, ¹⁵N is the ¹³C and ¹⁵N labeled L-Tyrosine[1]. L-Tyrosine is a non-essential amino acid which can inhibit citrate synthase activity in the posterior cortex[2].

HY-W109812S

Sinapyl alcohol-d3
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2 .

HY-B0631S

Alendronic acid-d6
Alendronic acid-d₆ is the deuterium labeled Alendronic acid. Alendronic acid, a bisphosphonate, is a farnesyl diphosphate synthase (FDPS) inhibitor. Alendronic acid inhibits osteoclast-mediated bone resorption. Alendronic acid shows efficacy in postmenopausal osteoporosis, malignant hypercalcemia and Paget’s disease[1].

HY-B1876S

Nicosulfuron-d6
Nicosulfuron-d₆ is the deuterium labeled Nicosulfuron[1]. Nicosulfuron is a selective herbicide belonging to the sulfonylurea family. Nicosulfuron is commonly used as a post-emergence herbicide to protect maize crops from weeds. Nicosulfuron inhibits acetolactate synthase (ALS) enzyme activity[2].

HY-10820S

Pemetrexed-d5
Pemetrexed-d₅ is the deuterium labeled Pemetrexed[1]. Pemetrexed (LY231514) is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[2].

HY-10820AS

Pemetrexed-d5 disodium
Pemetrexed-d₅ (disodium) is the deuterium labeled Pemetrexed disodium. Pemetrexed disodium (LY231514 disodium) is an antifolate, the Kis of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively[1].

HY-B0230S2

Phenylbutazone-13C12
Phenylbutazone- ¹³C₁₂ is the ¹³C₁₂ labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research.

HY-N6723S

Fumonisin B2-13C34
Fumonisin B2- ¹³C₃₄ is the ¹³C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis .

HY-B0230S

Phenylbutazone(diphenyl-d10)

Phenylbutazone(diphenyl-d₁₀) is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

HY-B0230S1

Phenylbutazone-d9
Phenylbutazone-d₉ is the deuterium labeled Phenylbutazone. Phenylbutazone is an efficient reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone, a hepatotoxin, is a nonsteroidal anti-inflammatory agent (NSAID). Phenylbutazone induces muscle blind-like protein 1 (MBNL1) expression and has the potential for ankylosing spondylitis research[1][2].

HY-100427S

Imazamox-13C,d3
Imazamox- ¹³C,d₃ is the ¹³C- and deuterium labeled Imazamox. Imazamox (CL29926) is a systemic herbicide that inhibits the production of acetolactate synthase (ALS) in plants with high selectivity, high activity, safety and broadspectrum activity, which would then inhibit plant growth and ultimately lead to plant death[1][2].

HY-B0503S

2-Thiouracil-13C,15N2
2-Thiouracil- ¹³C, ¹⁵N₂ is the ¹³C, ¹⁵N labeled 2-Thiouracil. 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil can function as a highly specific melanoma seeker. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM.

HY-A0061S

Trifluridine-13C,15N2
Trifluridine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Trifluridine[1]. Trifluridine (Trifluorothymidine;5-Trifluorothymidine;TFT) is an irreversible thymidylate synthase inhibitor, and thereby suppresses DNA synthesis. Trifluridine is an antiviral agent for herpes simplex virus (HSV) infection. Trifluorothymidine also has anti-orthopoxvirus activity[2].

HY-14881S2

Bedaquiline impurity 2-d6
Bedaquiline impurity 2-d₆ is deuterium labeled Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit[1]. Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis[2].

HY-B1448AS

(Rac)-Benidipine-d7
(Rac)-Benidipine-d₇ is the deuterium labeled Benidipine[1]. Benidipine is a potent and orally active calcium channel antagonist[2]. Benidipine shows anti-apoptosis effects in ischaemic/reperfused myocardial cells[3]. Benidipine increases the activity of endothelial cell-type nitric oxide synthase and improves coronary circulation in hypertensive rats[4].

HY-14881S1

(Rac)-Bedaquiline-d6
(Rac)-Bedaquiline-d₆is the deuterium labeledBedaquiline(HY-14881) . Bedaquiline (TMC207) is a diarylquinoline agent and inhibits Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase through targeting of both the c- and the ε-subunit . Bedaquiline has uncoupler activity. Bedaquiline is used for the multi-agent resistant tuberculosis .

HY-N6719S

Fumonisin B1-13C34
Fumonisin B1- ¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-N0157S1

Orotic acid-13C,15N2 monohydrate

Orotic acid- ¹³C, ¹⁵N₂ (monohydrate) is the ¹³C and ¹⁵N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

HY-125818S1

Cytidine-5′-triphosphate-d14 disodium

Cytidine-5′-triphosphate-d14 (disodium) is the deuterium labeled Cytidine-5'-triphosphate[1]. Cytidine 5′-triphosphate (Cytidine triphosphate;5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii[2].

Cat. No.	Product Name	Application	Reactivity

HY-P80694

*Glycogen Synthase* 1 Antibody** GYS1; GYS; Glycogen [starch] synthase; muscle	WB, ICC/IF, IP	Human, Rat
Glycogen Synthase 1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 84 kDa, targeting to Glycogen Synthase 1. It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Rat.

HY-P82792

Cyclooxygenase 1 Antibody (YA2537) PTGS1; COX1; Prostaglandin G/H synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Mouse, Rat

HY-P83072A

FDPS Antibody FPPS_HUMAN; Farnesyl pyrophosphate synthase; FPP synthase; FPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Geranyltranstransferase.	IHC-P, IHC-F, ICC, IF, ELISA	Rat, Mouse (predicted: Human)

HY-P80277

*Phospho-Glycogen synthase* 1 (S641) Antibody**	WB, ICC, IHC-P, IP	Human, Mouse, Rat
Phospho-Glycogen synthase 1 (S641) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 84 kDa, targeting to Phospho-Glycogen synthase 1(S641). It can be used for WB,ICC,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80668

*Fatty Acid Synthase* Antibody (YA766)** FASN; FAS; Fatty acid synthase	WB, ICC/IF, IP	Human, Mouse, Rat, Monkey
Fatty Acid Synthase Antibody (YA766) is a non-conjugated and Mouse origined monoclonal antibody about 273 kDa, targeting to Fatty Acid Synthase (2F9). It can be used for WB,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80128

*Fatty Acid Synthase* Antibody**	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
Fatty Acid Synthase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 273 kDa, targeting to Fatty Acid Synthase. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P83276

ALAS1 Antibody (YA3021)

ALAS1; ALAS-H; 5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; ALAS3; ALASH
WB, ICC/IF Human
HY-P83057

Citrate Synthetase Antibody (YA2802)

Citrate synthase; Citrate synthase; mitochondrial; Cs
WB, IHC-F, IHC-P, ICC/IF, IP Human, Rat

HY-P81191

Phospho-eNOS (Ser1177) Antibody eNOS (phospho S1177); eNOS(phospho S1177); p-eNOS (phospho S1177); eNOS (Phospho-Ser1177); cNOS; Constitutive NOS; EC NOS; ecNOS; Endothelial nitric oxidase synthase; Endothelial nitric oxide synthase; Endothelial nitric oxide synthase 3; Endothelial NOS; Nitric oxide synthase 3 (endothelial cell); Nitric oxide synthase 3; Nitric oxide synthase 3 endothelial cell; Nitric oxide synthase endothelial; nitric oxide synthase, endothelial; NOS 3; NOS III; NOS type III; NOS3; NOSIII; NOS3_HUMAN.	WB; ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse(predicted: Rat, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig)
Phospho-eNOS (Ser1177) Antibody is an unconjugated, approximately 133 kDa, rabbit-derived, anti-eNOS (Ser1177) polyclonal antibody. Phospho-eNOS (Ser1177) Antibody can be used for: WB, ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, and predicted: rat, dog, pig, cow, rabbit, sheep, guinea pig background without labeling.

HY-P81888

ATP Synthase C Antibody (YA1633)

ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1
WB, ICC/IF Human

HY-P80091

COX2/Cyclooxygenase 2 Antibody PTGS2; COX 2; COX2; COX-2; Cyclooxygenase; Cyclooxygenase2; Cyclooxygenase-2; hCox 2; PGG/HS; PGH synthase 2; PGHS 2; PGHS2; PHS 2; PHS II; PHS2 ; Prostaglandin endoperoxide synthase 2; Prostaglandin G/H synthase 2 precursor; Prostaglandin G/H synthase and cyclooxygenase; Prostaglandin G/H synthase 2; Prostaglandin H2 synthase 2; TIS10II; PGH2_HUMAN.	WB, ICC/IF, IHC-P	Human, Rat
COX2/Cyclooxygenase 2 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 69 kDa, targeting to COX2/Cyclooxygenase 2. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Rat.

HY-P80145

*Glycogen synthase* Antibody** GYS1	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
Glycogen synthase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 84 kDa, targeting to Glycogen synthase. It can be used for WB,ICC/IF,IHC-P,FC,IP assays with tag free, in the background of Human, Mouse.

HY-P82925

Thromboxane A Synthase Antibody (YA2670)

TBXAS1; CYP5; CYP5A1; Thromboxane-A synthase; TXA synthase; TXS; Cytochrome P450 5A1
WB Human, Mouse

HY-P81182

PTGES2 Antibody C9orf15; FLJ14038; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2; Prostaglandin E synthase 2 truncated form; PTGES 2; PGES2_MOUSE.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow)
PTGES2 Antibody is an unconjugated, approximately 43 kDa, rabbit-derived, anti-PTGES2 polyclonal antibody. PTGES2 Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow background without labeling.

HY-P80551

ASS1 Antibody Argininosuccinate synthase 1; ASS; ass1; ASSA; Citrulline aspartate ligase; CTLN1	WB, IHC-F, IHC-P, ICC/IF, IP	Human, Rat
ASS1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 47 kDa, targeting to ASS1. It can be used for WB,IHC-F,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Rat.

HY-P80973

*Thymidylate Synthase* Antibody** TS; TMS; HST422	WB, IHC-F, IHC-P, ICC/IF, IP	Human
Thymidylate Synthase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to thymidylate synthase. It can be used for WB, IHC-F, IHC-P, ICC/IF, IP assays with tag free, in the background of Human.

HY-P82460

ATP5G Antibody (YA2205)

ATP synthase lipid-binding protein; ATP synthase membrane subunit c locus 1
WB, IHC-P, IP Human, Rat
HY-P82298

Spermine Synthase Antibody (YA2043)

SRS; SpS; MRSR; SPMSY
WB Human

HY-P83386

p23 Antibody (YA3131) PTGES3; P23; TEBP; Prostaglandin E synthase 3; Cytosolic prostaglandin E2 synthase; cPGES; Hsp90 co-chaperone; Progesterone receptor complex p23; Telomerase-binding protein p23	WB, ICC/IF, IP	Human, Mouse, Rat

HY-P82829

CTP Synthase Antibody (YA2574)

CTPS; GATD5; IMD24
WB Human
HY-P82541

TRUB2 Antibody (YA2286)

Mitochondrial mRNA pseudouridine synthase TRUB2
WB Human
HY-P82796

Cyclooxygenase 2 Antibody (YA2541)

Cyclooxygenase-2; COX-2; Glucocorticoid-regulated inflammatory cyclooxygenase; Gripghs; PES-2; PHS II; Prostaglandin H2 synthase 2
WB, ICC/IF, IP Mouse

HY-P81072

LIAS Antibody HUSSY 01; LAS; LIP 1; Lip syn; LIP1; Lipoate synthase; Lipoic acid synthetase; Lipoic acid synthetase mitochondrial; Lipoyl synthase, mitochondrial; LS; MGC23245.	ELISA; IHC-P ; ICC; IF;	Mouse(predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep)
LIAS Antibody is an unconjugated, rabbit-derived, anti-LIAS polyclonal antibody. LIAS Antibody can be used for: ELISA, IHC-P, ICC, IF, expriments in mouse and predicted: human, rat, chicken, dog, pig, cow, horse, rabbit, sheep background without labeling.

HY-P81813

ELOVL5 Antibody (YA1558)

ELOVL FA elongase 5; Fatty acid elongase 1; hELO1; Very long chain 3-ketoacyl-CoA synthase 5
WB, ICC/IF Human

HY-P81002

FDFT1 Antibody DGPT; ERG9; FDFT1; SQS; Squalene synthase; SS	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
FDFT1 Antibody is an unconjugated, approximately 48 kDa, rabbit-derived, anti-FDFT1 monoclonal antibody. FDFT1 Antibody can be used for: WB, IHC-P, ICC/IF, IP expriments in human, mouse, rat background without labeling.

HY-P83316

HMBS Antibody (YA3061)

UPS; PBGD; PORC; PBG-D; HMBS; Hydroxymethylbilane synthase
WB Human, Mouse, Rat
HY-P82976

DPS1 Antibody (YA2721)

Trans-prenyltransferase 1; TPT 1; Solanesyl-diphosphate synthase subunit 1; Decaprenyl-diphosphate synthase subunit 1
WB, IP Human

HY-P80725

iNOS Antibody NOS2; NOS2A; Nitric oxide synthase; inducible; Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2	ICC/IF, WB, IHC-F, IHC-P, ELISA	Human, Mouse, Rat
iNOS Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 131 kDa, targeting to iNOS. It can be used for ICC/IF,WB,IHC-F,IHC-P,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P81994

Prostaglandin D Synthase Antibody (YA1739)

PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
WB, IHC-F, IHC-P, ICC/IF Human, Mouse, Rat

HY-P83060

HAPLN1 Antibody (YA2805) Hyaluronan and proteoglycan link protein 1; Cartilage-linking protein 1; Cartilage-link protein; Proteoglycan link protein; HAPLN1; CRTL1	WB, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P83478

MGST3 Antibody (YA3223)

Glutathione peroxidase MGST3; LTC4 synthase MGST3; Microsomal GST-III
WB, IHC-P, IP Human

HY-P80560

ATP Citrate Lyase Antibody (YA829) ACLY; ATP-citrate synthase; ATP-citrate; pro-S-)-lyase; ACL; Citrate cleavage enzyme	WB, ICC/IF, FC	Human, Mouse, Monkey
ATP Citrate Lyase Antibody (YA829) is a non-conjugated and Mouse origined monoclonal antibody about 121 kDa, targeting to ATP Citrate Lyase (3D9). It can be used for WB,ICC/IF,FC assays with tag free, in the background of Human, Mouse, Monkey.

HY-P80656

eNOS Antibody NOS3; Nitric oxide synthase; endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
eNOS Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 133 kDa, targeting to eNOS. It can be used for WB,IHC-F,IHC-P,ICC/IF,ELISA assays with tag free, in the background of Human, Mouse, Rat.

HY-P80625

Cleaved-PARP1 Antibody PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB	Human
Cleaved-PARP1 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 113 kDa, targeting to Cleaved-PARP1. It can be used for WB assays with tag free, in the background of Human.

HY-P80780

PARP1 Antibody (YA245) PARP1; ADPRT; PPOL; Poly [ADP-ribose] polymerase 1; PARP-1; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
PARP1 Antibody (YA245) is a non-conjugated and Rabbit origined monoclonal antibody about 113 kDa, targeting to PARP1. It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P83293

LIG1 Antibody (YA3038)

LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
WB, IHC-F, IHC-P, ICC/IF Human, Rat
HY-P82045

DNA Ligase I Antibody (YA1790)

LIG1; DNA ligase 1; DNA ligase I; Polydeoxyribonucleotide synthase [ATP] 1
WB, IHC-P, ICC/IF Human, Rat
HY-P82954

DNA Ligase IV Antibody (YA2699)

LIG4; DNA ligase 4; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4
WB Human

HY-P80698

GSK3 beta Antibody (YA744) GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B	WB, IHC-P, FC	Human, Mouse, Rat
GSK3 beta Antibody (YA744) is a non-conjugated and Mouse origined monoclonal antibody about 47 kDa, targeting to GSK3 beta. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80547

Aromatase Antibody CYP19A1; ARO1; CYAR; CYP19; Cytochrome P450 19A1; Aromatase; CYPXIX; Cytochrome P-450AROM; Estrogen synthase	WB, IP	Human, Mouse, Rat
Aromatase Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 58 kDa, targeting to Aromatase. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P80820

Phospho-GSK3 beta (Ser9) Antibody GSK3B; Glycogen synthase kinase-3 beta; GSK-3 beta; Serine/threonine-protein kinase GSK3B	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat
Phospho-GSK3 beta (Ser9) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 47 kDa, targeting to Phospho-GSK3 beta (Ser9). It can be used for WB,IHC-F,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse, Rat.

HY-P81996

Prostaglandin E Synthase Antibody (YA1741)

PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1
WB Human, Mouse, Rat

HY-P82566

GC1q R Antibody (YA2311) C1QBP; GC1QBP; HABP1; SF2P32; Complement component 1 Q subcomponent-binding protein; mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; C1qBP; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p33	WB, IP	Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-119323

7-Azido-4-methylcoumarin		Azide
7-Azido-4-methylcoumarin is a fluorescent hydrogen sulfide (H2S) probe. 7-Azido-4-methylcoumarin serves as a highly sensitive assay for cystathionine β-synthase activity .

HY-13728B

(Rac)-Plevitrexed (Rac)-ZD 9331; (Rac)-BGC9331		Alkynes
(Rac)-Plevitrexed ((Rac)-ZD 9331; (Rac)-BGC9331)?is a racemate of Plevitrexed. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor. (Rac)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-13728A

(R)-Plevitrexed (R)-ZD 9331; (R)-BGC9331		Alkynes
(R)-Plevitrexed ((R)-ZD 9331; (R)-BGC9331) is a less active enantiomer of Plevitrexed . Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor . (R)-Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-10822

Idetrexed BGC 945; ONX-0801		Alkynes
Idetrexed is a thymidylate synthase inhibitor specifically transported into alpha-folate receptor (alpha-FR)-overexpressing tumors. BGC 945 inhibited thymidylate synthase with a K_i of 1.2 nmol/L .

HY-10822A

ONX 0801 trisodium BGC 945 trisodium; Idetrexed trisodium; CB 300945 trisodium		Alkynes
ONX 0801 (BGC 945) trisodium is a *thymidylate synthase* (TS)** inhibitor, targeted to α-folate receptor–overexpressing tumors .

HY-13728

Plevitrexed ZD 9331; BGC9331		Alkynes
Plevitrexed (ZD 9331; BGC 9331) is an orally active and potent *thymidylate synthase* (TS) inhibitor with a K_i** of 0.44 nM. Plevitrexed is taken up via the α-folate receptor as well as the reduced folate carrier. Plevitrexed is used for gastric cancer in clinical . Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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